Finally, a rat-tail amputation model revealed that our SP-CH could even reduce bleeding time in vivo. It showed increased blood clotting capacity in vitro, as well as increased capacity to bind both red blood cells and platelets, compared to the standard gauze and Merocel. It was shown to be both biocompatible and hemocompatible in vitro, clearing up any doubt about its safety. Our SP-CH presented great physicochemical and mechanical properties, lost weight in aqueous medium, and could even partially degrade when incubated in blood. To evaluate the potential of our material as a nasal pack, it was compared with two of the most commonly used nasal packs in the clinic: a basic gauze and the gold standard Merocel. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-like scaffold (SP-CH) produced from natural by-products of the food industry - soy protein and beta-chitin - can be employed as a nasal pack for the treatment of epistaxis. Although there are currently several treatments available, they present several disadvantages. Epistaxis is one of the most common otorhinolaryngology emergencies worldwide.
0 kommentar(er)
